Although I love the TNG crew, to face Captain Picard and his crew in combat would be awesome. And they would have to be in the Enterprise-D, so they could separate into TWO ships for me to battle! I enjoy a good challenge!
And as a villain, I would hijack a Nebula-class, so it would be like a 24th century version of Enterprise VS Reliant!!! OMG, that would be freaking EPIC!!!
I could not face Kirk's crew, that would be heartbreaking. And the other crews seem like they'd be a cinch to blow up.
"To boldly go where no man has gone before"
--ADMIRAL JONATHAN ARCHER--