The question of serialization is an interesting one. On the one hand, it allows for depth. Serialization dominates the landscape right now in large part because it allows for such depth . But, that depth can come at a price. It can discourage new viewership from people who haven't been with you since the beginning. It's why I don't watch Fringe, even though it looks like something I would enjoy. I'll have to watch it from the beginning. And while it's on my to do list, I haven't gotten around to it.
I think that is the biggest challenge facing a new Trek series if they were to go the serialized route.