Orci in one ways is looking at the "big picture" ala will any changes in this film prohibit it from fitting with any of the other movies, and to a lesser point, will it necessarily prevent the general idea of the various TV shows from occurring.
So, will anything Nero do prevent the existence of Cardassia, or the Borg. No.
At most, I think the net talley of changes will be appearance of the ship, inside and out, and a few dialogue changes and missing actors in some of the episodes. Kirk will be chasing the cloud creature in Obsession because it killed his own crewmembers vs the revenge factor...but that doesn't change young Garrovick's story, because his father was still killed by it. Get what I'm saying Holmes.
I have seen the darkness in my soul and shine brighter for it.